Healthcare applications, such as patient record, patient – doctor mapping service, various disease symptoms etc. The major challenges is processing and integrating the real time data. Following-up with analyzing the data would involve moving the data in Data Lake to a Cloud to known about the status of the patient and for tracking purpose. In this research, we recommend a cloud based information integration framework using Data Lake in Cloud. This work extends the information integration architecture by designing with Data Lake in Cloud, using mathematical model (Petri Net) to verify architecture. This approach has the ability to scale up and down in real time data, and leading to efficient way of using data resources in the Cloud.