Guided by the sociocultural theory and input theory, a research was conducted to probe into resource-based and theme-oriented college English teaching. It discusses the principles of college English language materials selection and how theme-oriented teaching activities enhance meaningful language input and output. The results show that the teaching mode can improve students’ multiple intelligences on a large scale and facilitate the transformation between students’ explicit knowledge and tacit knowledge. Being resource-based and theme-oriented, the mode helps broaden students’ horizon, cultivate their humanistic quality, enhance students’ information quality and boost the effects of language learning.