When interference is reduced, the benefits of using a macrocell and femtocell heterogeneous network (Macro-Femto) heterogeneous network (HetNet) can be increased to their full potential. In this study, Enhanced Active Power Control (EAPC), Active Power Control (APC), and Power Control (PC1) interference mitigation strategies are applied, and their performances in uplink and downlink transmission of 5G Non-Stand-Alone (NSA) architecture are compared. According to the findings of a MATLAB simulation, the EAPC technique utilized a lower amount of transmit power for the Macro User Equipment (MUE), the Home User Equipment (HUE), and the femtocell logical node (Hen-gNB), in comparison to the APC and PC1 techniques. While PC1 approach required less en-gNB transmission power. The MUE, HUE, hen-gNB, and en-gNB throughput of the EAPC approach was much higher. This work will enable wireless system designers and network engineers know the appropriate technique to utilize to achieve desired Quality of Service (QoS) while conserving network resources.